Pichia Produced Products on the Market
RCT’s Pichia Expression Platform has enabled a wide range of protein products to enter the market for therapeutic and industrial uses. Several biopharmaceutical products produced in Pichia have been approved for human use by regulatory agencies such as the US Food and Drug Adminstration (FDA). The table below describes some of the more than 70 products that are on the market or in late stage development.
Product | Company | Use |
---|---|---|
AQUAVAC IPN (recombinant infectious pancreatic necrosis virus capsid proteins) | Merck/Schering Plough Animal Health (Summit, NJ) | Vaccines for infectious pancreatic necrosis in salmon |
Corbevax® (Protein sub-unit COVID-19 Vaccine) | Biological E. Limited (India) | COVID-19 vaccine |
Heparin-binding EGF-like growth factor (HB-EGF) | Trillium (Canada) | Treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) treatment |
Indovac (Recombinant COVID-19 Vaccine) | Biofarma (Indonesia) | COVID-19 vaccine |
Insugen® (recombinant human insulin) | Biocon (India) | Diabetes therapy |
Kalbitor® (DX-88 ecallantide, a recombinant kallikrein inhibitor protein) | Dyax (Cambridge, MA) | Hereditary angioedema treatment |
Medway (recombinant human serum albumin) | Mitsubishi Tanabe Pharma (Japan) | Blood volume expansion |
Nanobody® ALX-0061 (recombinant anti-IL6 receptor single domain antibody fragment) | Ablynx (Belgium) | Rheumatoid arthritis treatment |
Nanobody® ALX00171 (recombinant anti-RSV single domain antibody fragment) | Ablynx (Belgium) | Respiratory syncytial virus (RSV) infection treatment |
Ocriplasmin (recombinant microplasmin) | ThromboGenics (Belgium) | Vitreomacular adhesion (VMA) treatment |
Purifine (recombinant phospholipase C) | Verenium/DSM (San Diego, CA/Netherlands) | Degumming of high phosphorus oils |
Recombinant collagen | Fibrogen (San Francisco, CA) | Medical research reagents/dermal filler |
Recombinant human cystatin C | Scipac (United Kingdom) | Research reagent |
Recombinant phytase | Phytex, LLC (Sheridan, IN) | Animal feed additive |
Recombinant trypsin | Roche Applied Science (Germany) | Digestion of proteins |
Shanferon™ (recombinant interferon-alpha 2b) | Shantha/Sanofi (India) | Hepatitis C & Cancer treatment |
Shanvac ™ (recombinant hepatitis B vaccine) | Shantha/Sanofi (India) | Hepatitis B prevention |
Superior Stock recombinant nitrate reductase | The Nitrate Elimination Co. (Lake Linden, MI) | Enzyme-based products for water testing and water treatment |