Pichia Produced Products on the Market
RCT’s Pichia Expression Platform has enabled a wide range of protein products to enter the market for therapeutic and industrial uses. Several biopharmaceutical products produced in Pichia have been approved for human use by regulatory agencies such as the US Food and Drug Adminstration (FDA). The table below describes some of the more than 70 products that are on the market or in late stage development.
Product | Company | Use |
|---|---|---|
| Kalbitor® (DX-88 ecallantide, a recombinant kallikrein inhibitor protein) | Dyax (Cambridge, MA) | Hereditary angioedema treatment |
| Insugen® (recombinant human insulin) | Biocon (India) | Diabetes therapy |
| Medway (recombinant human serum albumin) | Mitsubishi Tanabe Pharma (Japan) | Blood volume expansion |
| Shanvac ™ (recombinant hepatitis B vaccine) | Shantha/Sanofi (India) | Hepatitis B prevention |
| Shanferon™ (recombinant interferon-alpha 2b) | Shantha/Sanofi (India) | Hepatitis C & Cancer treatment |
| Ocriplasmin (recombinant microplasmin) | ThromboGenics (Belgium) | Vitreomacular adhesion (VMA) treatment |
| Nanobody® ALX-0061 (recombinant anti-IL6 receptor single domain antibody fragment) | Ablynx (Belgium) | Rheumatoid arthritis treatment |
| Nanobody® ALX00171 (recombinant anti-RSV single domain antibody fragment) | Ablynx (Belgium) | Respiratory syncytial virus (RSV) infection treatment |
| Heparin-binding EGF-like growth factor (HB-EGF) | Trillium (Canada) | Treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) treatment |
| Purifine (recombinant phospholipase C) | Verenium/DSM (San Diego, CA/Netherlands) | Degumming of high phosphorus oils |
| Recombinant trypsin | Roche Applied Science (Germany) | Digestion of proteins |
| Recombinant collagen | Fibrogen (San Francisco, CA) | Medical research reagents/dermal filler |
| AQUAVAC IPN (recombinant infectious pancreatic necrosis virus capsid proteins) | Merck/Schering Plough Animal Health (Summit, NJ) | Vaccines for infectious pancreatic necrosis in salmon |
| Recombinant phytase | Phytex, LLC (Sheridan, IN) | Animal feed additive |
| Superior Stock recombinant nitrate reductase | The Nitrate Elimination Co. (Lake Linden, MI) | Enzyme-based products for water testing and water treatment |
| Recombinant human cystatin C | Scipac (United Kingdom) | Research reagent |
